Ah, the sobering realisation of one’s own mortal fragility. While not necessarily the chirpiest holiday topic, it’s certainly a topical holiday theme of late. Once relegated to elite athletes, medical facilities and Silicon Valley tycoons, the prevalence and accessibility of biohacking retreats, packages and protocols to enhance longevity have exploded in popularity in recent years as more of us seek to become less creaky versions of ourselves.
While easily confused with the pursuit of living forever (we’ll leave that to Bryan Johnson), longevity is about living longer and healthier lives. Even though our lifespans are increasing, our healthspans aren’t keeping pace, as the World Health Organisation points out, meaning we’re living longer, but the quality of our later years is declining, which is also putting increasing pressure on already strained healthcare systems. Biohacking offers a way to fast-track wellness, and while some methodologies are as scientifically sound as a horoscope, treatments like cryotherapy (popularised by cold-exposure fanatic Wim Hof), red-light therapy, hyperbaric oxygen therapy and ozone therapy have gained credibility within the scientific community.
Maybe you want the lungs of someone who has never graced the Fabric smoking area, eight solid hours of sleep every night or perhaps to become DiCaprio’s next conquest. Whatever your motivation, we’ve sussed out the best biohacking and longevity packages – from express one-hour protocols in London clinics to full-blown retreats in Okinawa, Koh Samui, Ibiza and beyond.
The best biohacking and longevity retreats to visit in 2025
Grand Resort Bad Ragaz
Switzerland
There’s something in the water at Grand Resort Bad Ragaz. No, like really. Located in the eponymous spa town, this part of Switzerland is famed for its healing thermal waters, which are harnessed at Grand Resort Bad Ragaz through its wellness offering. Benedictine monks discovered the hot spring back in 1242, quickly recognising the water’s healing effects – although it wasn’t until 1840 that these famed waters flowed through a 4km-long pipeline directly to Bad Ragaz. Alongside bathing in this thermal water with a temperature of 36.5°C shown to stimulate the metabolism, blood circulation and improve heart function, you can also partake in the NEWYOU Method programme at the hotel – proven to help maintain health, prevent disease and sustainably increase your quality of life. Perfect for those looking for a way into longevity that doesn’t involve a gazillion steps, machines and needles.
HOSHINOYA Okinawa
Okinawa
At Hoshinoya Okinawa, longevity isn’t just a wellness trend – it’s a way of life backed by centuries of Blue Zone wisdom. The folks in this Japanese prefecture know a thing or two about longevity, too, with an average life expectancy of 87 years for women and 80 for men and approximately 68 per 100,000 Okinawans living to become centenarians. You can get a slice of the knowledge with a stay at Hoshinoya Okinawa to sample its Blue Zone Stay experience first-hand. Here, you can trade cold plunges and IV drips for something more timeless: practising Ryukyu karate in a seaside dojo, soaking in nature-powered spa treatments, and chowing down on Okinawan dishes rich in antioxidants. The Okinawa Blue Zone Stay experience distils the island’s secrets into something more tangible than a supplement bottle – slow living, mindful movement, and a diet that has fueled some of the world’s longest-lived people. Biohacking, it turns out, might just be hiding in plain sight.
Palace Merano
South Tyrol
If you’re looking for a spa weekend awash with cucumber-covered eyes and pedicures, Palace Merano is not the place for you. The Detox for Longevity programme is a hardcore full-body reboot not designed for the faint-hearted. Upon arrival, doctors assess your metrics with blood tests before embarking on the regime: hydro-energetic treatments to wring you out, antioxidant-rich meals to rebuild you, and a blend of Traditional Chinese Medicine and Western science to divine exactly which ancient element – fire, wood, metal – you’ve been neglecting. Cupping, electro-acupuncture, and stern encouragement follow. It’s the kind of place where indulgence is exorcised with precision, and guests emerge looking well-rested and rejuvenated, ready to get ID’ed at your next pub excursion.
Minos Palace Resort
Crete
Want to leave your vacay feeling like a Greek god? Check into Minos Palace in Crete to sample its brand-spanking longevity hub – Nao – set to open in May 2025. Instead of conceiving treatments that feel more woo-woo than wellness, Nao takes the science of ageing seriously, armed with advanced diagnostics and a data-driven approach to keep your health in tip-top shape. At its core lies a pioneering approach to well-being, targeting the 12 biological hallmarks that drive ageing so guests can be guided on how to extend life and health spans. There’s PBM red-light therapy for cellular regeneration, cryotherapy for reduced inflammation and even vibroacoustic therapy, which uses sound frequencies to promote relaxation and better sleep. It’s not all lasers and acronyms, either. Nao also leans on the old school, blending ancient healing practices with modern tech. Dionys-yes!
The Longevity Spa Portrait Milano
Milan
Looking to stave off the inevitable? The Longevity Suite is where Milan’s wellness obsessives go to turn back time and get stuck into The Longevity Method. Born from the work of more than 20 years of research by the team of The Longevity Suite, this protocol melds cold, detox and mindfulness with treatments that balance health, conscious beauty, and mental energy designed to convince your cells they haven’t aged a day since Berlusconi’s first term. The highlight? Dry float therapy, which claims to simulate reduced gravity and return four hours of lost sleep in just 30 minutes – ideal for the insomniacs among us (or those who spent the night testing Milan’s Negroni supply). In contrast to The Longevity Spa’s pursuit of youth, the location is suitably historic – found inside Portrait Milano, a grandiose Ferragamo-run hotel housed in the former Archiepiscopal Seminar, which is believed to be Europe’s oldest and the world’s second biggest seminary.
RoseBar at Six Senses
Ibiza
While a typical trip to Ibiza might involve shaving years off your life (we’re looking at you Ushuaïa), a trip to Six Senses Ibiza locks in lasting youth. RoseBar at Six Senses is its one-of-a-kind longevity club, which blends rigorous science with spiritual well-being to enhance human health and lengthen lifespan through programmes designed to activate the body’s natural repair systems. Guided by Chief Medical Officer Dr Mark Hyman and an expert team in longevity and functional medicine, RoseBar has a glut of state-of-the-art equipment and available treatments on offer, from regenerative ozone therapy and IV Infusions to somatic therapy and shamanic healing. Ommmm.
Vidavii
London
Dry water massage at Vidavii
In need of a factory reset in the amount of time it takes you to finish an episode of Gavin & Stacey? Instead of carting yourself across the world, nip down to Vidavii, the UK’s first technology-based well-being circuit based in London. Designed for busy, time-poor professionals who need an instant energy hit and health boost that’s more than the usual flat white and turmeric shot, each circuit takes a mere 30 minutes. Kick things off with a cutting-edge 3D body measurement scan followed by an infrared light and ionised oxygen chamber before turning down the heat with whole-body cryotherapy at a bone-chilling -85°C. From there, it’s on to the first-of-its-generation lymphatic flow system, which uses alternating pressure waves to optimise cardiovascular, venous and lymphatic flow to help protect against infection before finishing with dry water massage to reduce tension and muscle pain. Phew!
Kamalaya Koh Samui
Koh Samui
Pack your bags, we’re heading for Koh Samui, and no, it’s not to check into The White Lotus. Kamalaya on Koh Samui is a temple of transformation where 17 bespoke wellness programmes are guided by the principles of traditional Chinese medicine, Ayurveda, naturopathy and functional medicine. While many retreats focus on the body, 2025 sees Kamalaya hone in on the brain with the launch of its dedicated Cognitive House and a brand-new Brain Enhancement programme for guests. Think of it as a biohacking boot camp for your grey matter, fuelled by scientific evidence, ancient wisdom and an ungodly amount of coconut water.
HUM2N
London
The hyperbaric oxygen chamber at HUM2N
For those looking to turn back the clock without clocking in the air miles, HUM2N, the next-gen health club in Knightsbridge, is where you need to be. Founded by Dr Enayat, HUM2N combines precision medicine with high-octane biohacking. Foot massages and ginger tea this is not. HUM2N offers services, from cryotherapy and hyperbaric oxygen therapy to bespoke gut protocols and IV drips (needlephobes, best stay at home). For those keen on diving deep into the cellular workings of your body, book a biomarker test for root cause insights led by a physician. New to HUM2N are treatment stacks that combine the best of the best in one session – from immunity boosts to longevity to metabolism.
